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pentobarbital will minimize the level or influence of tramadol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Diminished AUC of tramadol and the Energetic metabolite (O-desmethyltramadol) when coadministered with potent CYP3A4 and CYP2B6 inducerspentobarbital will minimize the level or effect of clarithromycin by imp